Types of Insulin

 

There are many types of insulin. All insulins help sugar to get inside the cell, but they are not all the same. Each type may be different in how fast it takes to start working. Each type may be different in howfast it takes to start working, how long it takes to control blood sugar, and how long it lasts in the body. These differences are important to know when learning about insulin so you will use your insulin in the right way.

•  Onset: the length of time after injection that insulin begins to work

•  Peak: the length of time after injection that the insulin takes to reach its maximum effect

•  Duration: the length of time that the insulin continues to work inside the body

Three major drug companies manufacture insulin in the United States. These are Sanofi-aventis, Eli Lilly, and Novo Nordisk.

Types of insulin available in the United States

Rapid-Acting: Administer within 15 minutes before a meal or eat within 5-15 minutes after injection.

Generic Name

Brand Name

Concentration

Manufacturer

insulin aspart

NovoLOG

100 units/mL

Novo Nordisk

insulin glulisine

APIDRA

100 units/mL

Sanofi-aventis

insulin lispro

HumaLOG

100 units/mL

Eli Lilly

insulin lispro (U-200)

HumaLOG KwikPen U-2001

200 units/mL

Eli Lilly

insulin (oral inhalation)

AFREZZA

Available in single-use cartridges of 4 units, 8 Units and 12 Units

Sanofi-aventis

insulin lispro

Admelog

100 units/mL

Sanofi

Insulin aspart

Fiasp

100 units/mL

Novo Nordisk

Short-Acting: Takes effect within 30 minutes. The max effect is between 2.5 hours-5 hours. The duration is approximately 8 hours.

Generic Name

Brand Name

Concentration

Manufacturer

insulin regular

HumuLIN R2

100 units/mL

Eli Lilly

insulin regular

NovoLIN R2

100 units/mL

Novo Nordisk

insulin regular (U-500)

HumuLIN R U-500 Concentrated

500 units/mL

Eli Lilly

Intermediate-Acting: Takes effect with 90 minutes of injection. The greatest blood sugar lowering effect is between 4 and 12 hours after the injection. This blood sugar lowering may last up to 24 hours.

Generic Name

Brand Name

Concentration

Manufacturer

NPH

HumuLIN N

100 units/mL

Eli Lilly

NPH

NovoLIN N

100 units/mL

novo Nordisk

Long-Acting: Provides slow steady release of insulin (*no pronounced peak). Duration up to 24 hours.

Generic Name

Brand Name

Concentration

Manufacturer

insulin detemir

LEVEMIR

100 units/mL

Novo Nordisk

insulin glargine

LANTUS

100 units/mL

Sanofi-aventis

insulin glargine (U-300)

TOUJEO1

300 units/mL

Sanofi-aventis

insulin glargine

Basaglar

100 units/mL

Lilly

Insulin glargine + Lixisenatide

Soliqua

100 units/mL & 33 mcg/mL

Sanofi

Ultralong-Acting: Insulin degludec has an onset of action of 30–90 minutes and has a duration of action that lasts up to 42 hours.

Generic Name

Brand Name

Concentration

Manufacturer

insulin degludac

TRESIBA*,1

100 units/mL

Novo Nordisk

Insulin degludec + liraglutide

Xultophy

100 units/mL & 3.6 mg/mL

Novo nordisk

insulin degludac (U-200)

TRESIBA*,1

200 units/mL

Novo Nordisk

Mixtures

Generic Name

Brand Name

Concentration

Manufacturer

75% insulin lispro protamine and 25% insulin lispro

HumaLOG Mix 75/25

100 units/mL

Eli Lilly

50% insulin lispro protamine and 50% insulin lispro

HumaLOG Mix 50/50

100 units/mL

Eli Lilly

70% NPH and 30% insulin regular

HumuLIN 70/30

100 units/mL

Eli Lilly

70% NPH and 30% insulin regular

NovoLIN 70/30

100 units/mL

Novo Nordisk

70% aspart protamine and 30% insulin aspart

NovoLOG Mix 70/30

100 units/mL

Novo Nordisk

70% insulin degludec, 30% insulin aspart

RYZODEG 70/30*,1

100 units/mL

Novo Nordisk

1Available in pen device only

list updated August 2018

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