Medicine Safety Tips

Drugs That Should Not Be Crushed

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Mistakes can occur when people have trouble swallowing a tablet or capsule and they try to chew, crush, break or mix the tablet or capsule in food or drink. The reason is certain medications have a special release mechanism designed to slowly release a certain amount of medication over a given extended time. If the medication is altered or destroyed in any way, the medication can be released too fast and cause a bad effect.

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Medication Name
Abilify MyCite kit
(aripiprazole)
Tablet
Comment
Drug-device combination
Medication Name
Absorica
(ISOtretinoin)
Capsule
Comment
Mucous membrane irritant
Medication Name
Abstral
(fentaNYL)
Tablet
Comment
Note: Sublingual tablet; do not suck, chew, or swallow whole.
Medication Name
AcipHex
(rabeprazole)
Tablet
Comment
Slow-release
Medication Name
AcipHex Sprinkle
(rabeprazole)
Capsule
Comment
Slow-release; Note: contents are intended to be sprinkled on food or liquid but should not be chewed or crushed.
Medication Name
Acticlate
(doxycycline hyclate)
Capsule; Tablet
Comment
Film-coated; tablet is scored and may be split; Note: 150 mg tablets can be broken into two-thirds or one-third to provide a 100 mg and 50 mg strength, respectively
Medication Name
Actiq
(fentaNYL)
Lozenge
Comment
Slow-release; Note: this lollipop delivery system requires the patient to slowly allow dissolution. If chewed and swallowed, may result in a lower peak concentration and bioavailability.
Medication Name
Actonel
(risedronate)
Tablet
Comment
Irritant; Note: chewed, crushed, or sucked tablets may cause oropharyngeal ulceration.
Medication Name
Actoplus Met Xr
(combination)
Tablet
Comment
Slow-release
Medication Name
Adalat CC
(NIFEdipine)
Tablet
Comment
Slow-release
Medication Name
Adderall XR
(amphetamine salts)
Capsule
Comment
Slow-release (a)
Medication Name
Adhansia XR
(methylephenidate hydrochloride)
Capsule
Comment
Slow-release (a)
Medication Name
Adzenys XR-ODT
(amphetamine)
Tablet
Comment
Slow-release; Sublingual form (g)
Medication Name
Aemcolo
(rifamycin)
Tablet
Comment
Slow-release
Medication Name
Afeditab CR
(NIFEdipine)
Tablet
Comment
Slow-release
Medication Name
Afinitor
(everolimus)
Tablet
Comment
Mucous membrane irritant
Medication Name
Aggrenox
(combination)
Capsule
Comment
Slow-release
Medication Name
Alecensa
(alectinib)
Capsule
Comment
Antineoplastic
Medication Name
Alophen
(bisacodyl)
Tablet
Comment
Enteric-coated
Medication Name
Altoprev
(lovastatin)
Tablet
Comment
Slow-release
Medication Name
Alunbrig
(brigantinib)
Tablet
Comment
Antineoplastic
Medication Name
Ambien CR
(zolpidem)
Tablet
Comment
Slow-release
Medication Name
Amitiza
(lubiprostone)
Capsule
Comment
-
Medication Name
Amnesteem
(ISOtretinoin)
Capsule
Comment
Mucous membrane irritant
Medication Name
Ampyra
(dalfampridine)
Tablet
Comment
Slow-release; Note: formerly fampridine-SR
Medication Name
Amrix
(cyclobenzaprine)
Capsule
Comment
Slow-release (a)
Medication Name
Aplenzin
(buPROPion)
Tablet
Comment
Slow-release
Medication Name
Aptensio XR
(methylphenidate)
Capsule
Comment
Slow-release (a)
Medication Name
Aptivus
(tipranavir)
Capsule
Comment
Note: oil emulsion within spheres; taste
Medication Name
Arakoda
(tafenoqunie succinate)
Tablet
Comment
-